Leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4/GPR48), a member of
the GPCR (G protein-coupled receptors) superfamily, subfamily B, is a common intestinal …

Colorectal cancer (CRC), is an emerging cause of cancer-related mortalities globally, results
from the buildup of numerous genetic and epigenetic variations in the normal colonic and …

Female-to-male sex reversals (pseudomales) are common in lower vertebrates and have
been found in natural populations, which is a concern under rapid changes in environmental …

Haploinsufficiency for SOX9, the master chondrogenesis transcription factor, can underlie
campomelic dysplasia (CD), an autosomal dominant skeletal malformation syndrome …

The mammalian intestine is one of the most rapidly self-renewing tissues, driven by stem
cells residing at the crypt bottom. Paneth cells form a major element of the niche …

The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity and subsequent work has now demonstrated its importance in critical and …

The small intestine is among the fastest self-renewing tissues in adult mammals. This rapid
turnover is fueled by the intestinal stem cells residing in the intestinal crypt. Wnt signaling …

Wnt signaling plays a crucial role in embryonic development and homeostasis maintenance.
Delicate and sensitive fine-tuning of Wnt signaling based on the proper timings and …

During Caenorhabditis elegans development, multiple cells migrate long distances or
extend processes to reach their final position and/or attain proper shape. The Wnt signalling …

Background Rheumatoid arthritis (RA) can cause irreversible joint injury and serious
disability. This study aimed to investigate how TRIM33 regulated by KLF9 affects the …