Silymarin contains a group of closely-related flavonolignan compounds including silibinin,
and is extracted from Silybum marianum species, also called milk thistle. Silymarin has been …

The body's microbiome, composed of microbial cells that number in the trillions, is involved
in human health and disease in ways that are just starting to emerge. The microbiome is …

Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …

Colorectal cancer (CRC) is a heterogeneous disease in which unique subtypes are
characterized by distinct genetic and epigenetic alterations. Here we performed …

Nasopharayngeal carcinoma (NPC) is an Epstein–Barr virus–associated malignancy most
common in East Asia and Africa. Here we report frequent downregulation of the microRNA …

Over the past few years, several genes, proteins and signalling pathways that are required
for embryogenesis have been shown to regulate tumour development and progression by …

The incidence of oral squamous cell carcinoma (OSCC) is rising rapidly in developed
countries, posing a growing challenge due to the poor management of this type of …

The Slit family is a family of secreted proteins that play important roles in various physiologic
and pathologic activities via interacting with Robo receptors. Slit/Robo signaling was first …

In humans and domestic mammals, pivotal processes in ovary development, including
primordial follicle assembly, occur prenatally. These events are essential for determining …

Mouse models of cancers are routinely used to study cancer biology. However, it remains
unclear whether carcinogenesis in mice is driven by the same spectrum of genomic …