Abstract The Framingham Heart Study (FHS) was established in 1948 to improve
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …

The past year has witnessed substantial advances in understanding the genetic basis of
many common phenotypes of biomedical importance. These advances have been the result …

Mendelian randomization (MR) permits causal inference between exposures and a disease.
It can be compared with randomized controlled trials. Whereas in a randomized controlled …

Cardiovascular disease is the most common cause of morbidity and mortality globally.
Epidemiological studies using high‐sensitivity assays for serum C‐reactive protein have …

Genome-wide association (GWA) studies use high-throughput genotyping technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …

Background Identification of single nucleotide polymorphisms (SNPs) associated with gene
expression levels, known as expression quantitative trait loci (eQTLs), may improve …

Asthma, a chronic airway disease with known heritability, affects more than 300 million
people around the world. A genome-wide association (GWA) study of asthma with 359 …

Background The number of genome-wide association studies (GWAS) is growing rapidly
leading to the discovery and replication of many new disease loci. Combining results from …

Background About one quarter of adults are hypertensive and high blood pressure carries
increased risk for heart disease, stroke, kidney disease and death. Increased arterial …

Hypertension places a major burden on individual and public health, but the genetic basis of
this complex disorder is poorly understood. We conducted a genome-wide association study …