Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …

Tissue transglutaminase (TG2) is a widely distributed multifunctional protein involved in a
broad range of cellular and metabolic functions carried out in a variety of cellular …

Abstract Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that
catalyzes Ca (2+)-dependent protein modifications. In addition to being an enzyme, TG2 …

Overcoming intrinsic and acquired drug resistance is a major challenge in treating cancer.
Poor responses to drug treatment can result in metastasis, cancer dissemination and death …

Recent studies indicate that cancer cells express elevated levels of type II transglutaminase
(TG2), and that expression is further highly enriched in cancer stem cells derived from these …

Tissue transglutaminase (TG2) is a multifunctional enzyme involved in the cross-linking of
extracellular matrix proteins, formation of complexes with fibronectin (FN) and integrins, and …

Constitutive activation of nuclear factor kappa B (NF-κB) has been linked with
carcinogenesis and cancer progression, including metastasis, chemoresistance, and …

TGM2 is a stress-responsive gene that encodes a multifunctional and structurally complex
protein called tissue transglutaminase (abbreviated as TG2 or tTG). TGM2 expression is …

Several members of the Poly (ADP-ribose) polymerase (PARP) family are essential
regulators of genome integrity, actively prospected as drug targets for cancer therapy …