Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
infection and have been suggested to be a useful correlate of protection for vaccine clinical …
Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy
Humoral immune responses are characterized by complex mixtures of polyclonal antibody
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity
MD Larsen, EL de Graaf, ME Sonneveld, HR Plomp… - Science, 2021 - science.org
INTRODUCTION Antibody function is often considered static and mostly determined by
isotype and subclass. The conserved N-linked glycan at position 297 in the Fc domain of …
isotype and subclass. The conserved N-linked glycan at position 297 in the Fc domain of …
Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
Proinflammatory IgG Fc structures in patients with severe COVID-19
S Chakraborty, J Gonzalez, K Edwards… - Nature …, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 infections can cause coronavirus disease
2019 (COVID-19), which manifests with a range of severities from mild illness to life …
2019 (COVID-19), which manifests with a range of severities from mild illness to life …
Fc-mediated antibody effector functions during respiratory syncytial virus infection and disease
EA Van Erp, W Luytjes, G Ferwerda… - Frontiers in …, 2019 - frontiersin.org
Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections
and hospitalization in infants under 1 year of age and there is currently no market-approved …
and hospitalization in infants under 1 year of age and there is currently no market-approved …
Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity
S Chakraborty, JC Gonzalez, BL Sievers… - Science Translational …, 2022 - science.org
A damaging inflammatory response is implicated in the pathogenesis of severe coronavirus
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …
disease 2019 (COVID-19), but mechanisms contributing to this response are unclear. In two …
[HTML][HTML] An integrated multi-omic single-cell atlas of human B cell identity
B cells are capable of a wide range of effector functions including antibody secretion,
antigen presentation, cytokine production, and generation of immunological memory. A …
antigen presentation, cytokine production, and generation of immunological memory. A …
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Abstract Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell
responses in patients with cancer but PD-1 is also expressed by other immune cells …
responses in patients with cancer but PD-1 is also expressed by other immune cells …
mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses …
JS Buhre, T Pongracz, I Künsting, AS Lixenfeld… - Frontiers in …, 2023 - frontiersin.org
Background The new types of mRNA-containing lipid nanoparticle vaccines BNT162b2 and
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …
mRNA-1273 and the adenovirus-based vaccine AZD1222 were developed against SARS …