Every cell in nature carries a rich surface coat of glycans, its glycocalyx, which constitutes
the cell's interface with its environment. In eukaryotes, the glycocalyx is composed of …

Traumatic brain injury (TBI) is one of the leading causes of death of young people in the
developed world. In the United States alone, 1.7 million traumatic events occur annually …

Protein S-acylation, the only fully reversible posttranslational lipid modification of proteins, is
emerging as a ubiquitous mechanism to control the properties and function of a diverse …

Peripheral nerves injuries result in paralysis, anesthesia and lack of autonomic control of the
affected body areas. After injury, axons distal to the lesion are disconnected from the …

In addition to their adhesive functions, cell-adhesion molecules modulate signal-
transduction pathways by interacting with molecules such as receptor tyrosine kinases …

Protein palmitoylation, a classical and common lipid modification, regulates diverse aspects
of neuronal protein trafficking and function. The reversible nature of palmitoylation provides …

Maintenance of epithelial tissues needs the stroma. When the epithelium changes, the
stroma inevitably follows. In cancer, changes in the stroma drive invasion and metastasis …

Recognition molecules of the immunoglobulin superfamily have important roles in neuronal
interactions during ontogeny, including migration, survival, axon guidance and synaptic …

Fibroblast growth factors (FGFs) act as key signalling molecules in brain development,
maintenance, and repair. They influence the intricate relationship between myelinating cells …

Intercellular communication involves either direct cell-cell contact or release and uptake of
diffusible signals, two strategies mediated by distinct and largely nonoverlapping sets of …