In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Brain and retinal organoids are functional and dynamic in vitro three-dimensional (3D)
structures derived from pluripotent stem cells that spontaneously organize themselves to …

Species differences in brain and blood–brain barrier (BBB) biology hamper the translation of
findings from animal models to humans, impeding the development of therapeutics for brain …

Neural interfaces are evolving at a rapid pace owing to advances in material science and
fabrication, reduced cost of scalable complementary metal oxide semiconductor (CMOS) …

Laminins (LNs) are key components in the extracellular matrix of neuronal tissues in the
developing brain and neural stem cell niches. LN‐presenting hydrogels can provide a …

Three-dimensional (3D) cultures, so-called organoids, have emerged as an attractive tool for
disease modeling and therapeutic innovations. Here, we aim to determine if boundary cap …

Human organoids are small, self-organized, three-dimensional (3D) tissue cultures that
have started to revolutionize medical science in terms of understanding disease, testing …

The human brain and central nervous system (CNS) present unique challenges in drug
development for neurological diseases. One major obstacle is the blood–brain barrier …

Human cerebral organoids are an exciting and novel model system emerging in the field of
neurobiology. Cerebral organoids are spheres of self-organizing, neuronal lineage tissue …

With the advent of human-induced pluripotent stem cells (hiPSCs) and differentiation
protocols, methods to create in-vitro human-derived neuronal networks have been …