Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a recently defined entity
that includes rare kidney diseases characterized by tubular damage and interstitial fibrosis …

Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney
and is the most abundant protein in normal urine. The function of uromodulin remains …

Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary
protein in physiological conditions. Already described several decades ago, uromodulin has …

Eukaryotic cells contain an elegant protein quality control system that is crucial in
maintaining cellular homeostasis; however, dysfunction of this system results in …

Uromodulin, the most abundant protein in normal urine, is essentially produced by the cells
lining the thick ascending limb. There it regulates the activity of the cotransporter NKCC2 …

The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein
excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …

High-resolution spatial transcriptomics enables mapping of RNA expression directly from
intact tissue sections; however, its utility for the elucidation of disease processes and …

The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in
kidney and cardiovascular research. Genome-wide association studies discovered variants …

Background Uromodulin, the most abundant protein excreted in normal urine, plays major
roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of …

Background Mutation of HNF1B, the gene encoding transcription factor HNF-1β, is one
cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by …