O Devuyst, E Olinger, L Rampoldi - Nature Reviews Nephrology, 2017 - nature.com
Uromodulin (also known as Tamm-Horsfall protein) is exclusively produced in the kidney and is the most abundant protein in normal urine. The function of uromodulin remains …
C Schaeffer, O Devuyst… - Annual review of …, 2021 - annualreviews.org
Uromodulin, a protein exclusively produced by the kidney, is the most abundant urinary protein in physiological conditions. Already described several decades ago, uromodulin has …
Eukaryotic cells contain an elegant protein quality control system that is crucial in maintaining cellular homeostasis; however, dysfunction of this system results in …
N Tokonami, T Takata, J Beyeler, I Ehrbar, A Yoshifuji… - Kidney international, 2018 - Elsevier
Uromodulin, the most abundant protein in normal urine, is essentially produced by the cells lining the thick ascending limb. There it regulates the activity of the cotransporter NKCC2 …
E Olinger, C Schaeffer, K Kidd… - Proceedings of the …, 2022 - National Acad Sciences
The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein excreted in normal urine. Rare large-effect variants in UMOD cause autosomal dominant …
JL Marshall, T Noel, QS Wang, H Chen, E Murray… - Iscience, 2022 - cell.com
High-resolution spatial transcriptomics enables mapping of RNA expression directly from intact tissue sections; however, its utility for the elucidation of disease processes and …
S Mary, P Boder, S Padmanabhan, MW McBride… - …, 2022 - Am Heart Assoc
The exclusive expression of uromodulin in the kidneys has made it an intriguing protein in kidney and cardiovascular research. Genome-wide association studies discovered variants …
CB Joseph, M Mariniello, A Yoshifuji… - Journal of the …, 2022 - journals.lww.com
Background Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of …
SC Chan, Y Zhang, A Shao, S Avdulov… - Journal of the …, 2018 - journals.lww.com
Background Mutation of HNF1B, the gene encoding transcription factor HNF-1β, is one cause of autosomal dominant tubulointerstitial kidney disease, a syndrome characterized by …