Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Our brains consist of 80% water, which is continuously shifted between different
compartments and cell types during physiological and pathophysiological processes …

The neurone-centred view of the past disregarded or downplayed the role of astroglia as a
primary component in the pathogenesis of neurological diseases. As this concept is …

Epilepsy is characterized by recurrent spontaneous seizures due to hyperexcitability and
hypersynchrony of brain neurons. Current theories of pathophysiology stress neuronal …

Epilepsy is a complex neurological syndrome characterized by seizures resulting from
neuronal hyperexcitability and sudden and synchronized bursts of electrical discharges …

Aquaporin-4 (AQP4) is one of the most abundant molecules in the brain and is particularly
prevalent in astrocytic membranes at the blood-brain and brain-liquor interfaces. While …

The human brain contains two major cell populations, neurons and glia. While neurons are
electrically excitable and capable of discharging short voltage pulses known as action …

Research on glial cells over the past 30 years has confirmed the critical role of astrocytes in
pathophysiological brain states. However, most of our knowledge about astrocyte …

Tissue-and cell-specific deletion of the Aqp4 gene is required to differentiate between the
numerous pools of aquaporin-4 (AQP4) water channels. A glial-conditional Aqp4 knockout …

Kir4. 1 is an inwardly rectifying K+ channel expressed exclusively in glial cells in the central
nervous system. In glia, Kir4. 1 is implicated in several functions including extracellular K+ …