Mechanisms and clinical evidence to support melatonin's use in severe COVID-19 patients to lower mortality

DX Tan, RJ Reiter - Life Sciences, 2022 - Elsevier
The fear of SARS-CoV-2 infection is due to its high mortality related to seasonal flu. To date,
few medicines have been developed to significantly reduce the mortality of the severe …

The coronavirus disease 2019 (COVID-19): key emphasis on melatonin safety and therapeutic efficacy

E Ramos, F Lopez-Munoz, E Gil-Martin, J Egea… - Antioxidants, 2021 - mdpi.com
Viral infections constitute a tectonic convulsion in the normophysiology of the hosts. The
current coronavirus disease 2019 (COVID-19) pandemic is not an exception, and therefore …

Potential utility of melatonin in deadly infectious diseases related to the overreaction of innate immune response and destructive inflammation: focus on COVID-19

DX Tan, R Hardeland - Melatonin Research, 2020 - melatonin-research.net
The high mortality of deadly virus infectious diseases including SARS, MERS, COVID-19,
and avian flu is often caused by the uncontrolled innate immune response and destructive …

Aryl hydrocarbon receptor role in co-ordinating SARS-CoV-2 entry and symptomatology: linking cytotoxicity changes in COVID-19 and cancers; modulation by racial …

G Anderson, A Carbone, G Mazzoccoli - Biology, 2020 - mdpi.com
There is an under-recognized role of the aryl hydrocarbon receptor (AhR) in co-ordinating
the entry and pathophysiology of the severe acute respiratory syndrome-coronavirus-2 …

Psycho-neuro-endocrine-immunology: A role for melatonin in this new paradigm

OK Bitzer-Quintero, GG Ortiz, S Jaramillo-Bueno… - Molecules, 2022 - mdpi.com
Psychoneuroendocrinoimmunology is the area of study of the intimate relationship between
immune, physical, emotional, and psychological aspects. This new way of studying the …

Immunoregulatory properties of melatonin in the humoral immune system: A narrative review

JR Calvo, MD Maldonado - Immunology letters, 2024 - Elsevier
Melatonin is the major product both synthesized and secreted by the pineal gland during the
night period and it is the principal chronobiotic hormone that regulates the circadian rhythms …

Therapeutic benefits of melatonin against COVID-19

M Mubashshir, N Ahmad, T Negi, R Rawal… - …, 2023 - karger.com
The assumption of the pineal hormone melatonin as a therapeutic use for COVID-19-
affected people seems promising. Its intake has shown significant improvement in the …

Exogenous melatonin as potential adjuvant in anti-SarsCov2 vaccines

G Maestroni - Journal of Neuroimmune Pharmacology, 2020 - Springer
Dear Prof. Gendelman: Melatonin MLT) or N-acetyl-5-methoxy-tryptamine is an indoleamine
synthesized and immediately secreted in the blood during the night darkness hours by the …

Melatonin alleviates T-2 toxin-induced oxidative damage, inflammatory response, and apoptosis in piglet spleen and thymus

C Ning, W Xiao, Z Liang, Y Wu, H Fan, S Wang… - International …, 2024 - Elsevier
T-2 toxin, an unavoidable contaminant in animal feeds, can induce oxidative stress and
damage immune organs. Melatonin (MT), a natural and potent antioxidant, has shown …

Effects of exogenous melatonin on the postweaning immune response and growth performance of crossbred beef calves

AE Martin, VS Machado, RJ Rathmann… - Applied Animal …, 2024 - Elsevier
Objective Our objective was to evaluate the effects of exogenous melatonin on the immune
response and growth performance of beef calves during a vaccination series at weaning …