Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

Mitochondria play a key role in both health and disease. Their function is not limited to
energy production but serves multiple mechanisms varying from iron and calcium …

Chronic psychosocial stress increases disease risk and mortality, but the underlying
mechanisms remain largely unclear. Here we outline an energy-based model for the …

Most cells constitutively secrete mitochondrial DNA and proteins in extracellular vesicles
(EVs). While EVs are small vesicles that transfer material between cells, Mitochondria …

There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy,
aging-related diseases, and mortality. We examined potential advanced brain aging in adult …

Platelets are abundant, small, anucleate circulating cells, serving many emerging
pathophysiological roles beyond hemostasis; including active critical roles in thrombosis …

Extracellular vesicles (EVs) have emerged in the last decade as critical cell-to-cell
communication devices used to carry nucleic acids and proteins between cells. EV cargo …

Major depressive disorder (MDD) is characterized by psychological and physiological
manifestations contributing to the disease severity and outcome. In recent years, several …