Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …

Cervical cancer is one of the foremost common cancers in women. Human papillomavirus
(HPV) infection remains a major risk factor of cervical cancer. In addition, numerous other …

The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …

Multiple signatures of somatic mutations have been identified in cancer genomes. Exome
sequences of 1,001 human cancer cell lines and 577 xenografts revealed most common …

The past several years have seen an explosion in development of applications for the
CRISPR-Cas9 system, from efficient genome editing, to high-throughput screening, to …

Post-transcriptional modifications have been recently expanded with the addition of RNA
editing, which is predominantly mediated by adenosine and cytidine deaminases acting on …

Several recent studies have converged upon the innate immune DNA cytosine deaminase
APOBEC3B (A3B) as a significant source of genomic uracil lesions and mutagenesis in …

Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare and distinct subtype of
primary lung cancer characterized by Epstein-Barr virus (EBV) infection. Herein, we reported …

Human papillomavirus (HPV) is a necessary but insufficient cause of a subset of oral
squamous cell carcinomas (OSCCs) that is increasing markedly in frequency. To identify …

Chronic hepatitis B virus (HBV) infection imposes a severe burden on global public health.
Currently, there are no curative therapies for millions of chronic HBV-infected patients …