Streamlined data-driven drug discovery remains challenging, especially in resource-limited
settings. We present ZairaChem, an artificial intelligence (AI)-and machine learning (ML) …

Malarial parasites have been reported for moderate-high resistance towards classical
antimalarial agents and henceforth development of newer novel chemical entities targeting …

People from low-income countries are increasingly affected by neglected communicable
diseases, and the health care system frequently overlooks their needs. Currently, these …

Modern organic chemistry is a titan supporting and reinforcing pharmaceutical, agricultural,
food and material science products. Over the past decades, the organic compounds market …

Amodiaquine (AQ) is a potent antimalarial drug used in combination with artesunate as part
of artemisinin-based combination therapies (ACTs) for malarial treatment. Due to the rising …

Widespread Plasmodium falciparum resistance to first-line antimalarials underscores the
vital need to develop compounds with novel modes of action and identify new druggable …

In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide
pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of …

In the absence of a highly efficacious vaccine, chemotherapy remains the cornerstone to
control malaria morbidity and mortality. The threat of the emergence of parasites resistant to …

We previously identified a novel class of antimalarial benzimidazoles incorporating an
intramolecular hydrogen bonding motif. The frontrunner of the series, analogue A, showed …

This density functional theory (DFT) study reveals a detailed plausible mechanism for the Sc-
catalyzed C–H cycloaddition of imidazoles to 1, 1-disubstituted alkenes to form all-carbon …