The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

The ionotropic glutamate receptors are ligand-gated ion channels that mediate the vast
majority of excitatory neurotransmission in the brain. The cloning of cDNAs encoding …

Ionotropic glutamate receptors (iGluRs) mediate excitatory synaptic transmission in
vertebrates and invertebrates through ligand-induced opening of transmembrane ion …

NMDA receptors require both L-glutamate and the coagonist glycine for efficient channel
activation. The glycine binding site of these heteromeric receptor proteins is formed by …

Forty years of research into the function of l-glutamic acid as a neurotransmitter in the
vertebrate central nervous system (CNS) have uncovered a tremendous complexity in the …

▪ Abstract A vast number of proteins are involved in synaptic function. Many have been
cloned and their functional role defined with varying degrees of success, but their number …

France rather than the tertiary folding within each individual subunit. In other words, the
cooperative interactions The concept of allosteric proteins was initially proposed between …

Abstract Desensitization of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionate (AMPA)
receptors is thought to shape the synaptic response and act as a neuroprotective …

The NMDA type of ligand-gated glutamate receptor requires the presence of both glutamate
and glycine for gating. These receptors are hetero-oligomers of NR1 and NR2 subunits …

Identification of all residues involved in the recognition and binding of cholinergic ligands
(eg agonists, competitive antagonists, and noncompetitive agonists) is a primary objective to …