Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-β
peptides, and the family of β-sheet fibrils have been shown to contribute to a number of …

Chronic inflammation is a complex process that promotes carcinogenesis and tumor
progression; however, the mechanisms by which specific inflammatory mediators contribute …

Abstract The Receptor for Advanced Glycation Endproducts [RAGE] is an evolutionarily
recent member of the immunoglobulin super-family, encoded in the Class III region of the …

The Receptor for Advanced Glycation Endproducts (RAGE) is a multi-ligand receptor of the
immunoglobulin family. RAGE interacts with structurally different ligands probably through …

The age-related neurodegenerative disorders such as Alzheimer's, Parkinson's, and
Huntington's diseases are characterized by the abnormal accumulation or aggregation of …

The pattern recognition receptor or receptor for AGE (RAGE) is constitutionally expressed in
a few cell types only. However in almost all cells studied so far it is induced by reactions …

Endothelial dysfunction is a key triggering event in atherosclerosis. Following the entry of
lipoproteins into the vessel wall, their rapid modification results in the generation of …

Inflammatory mediators play important roles in the development and progression of cancer.
Cellular stress, damage, inflammation, and necrotic cell death cause release of endogenous …

Patients with inflammatory bowel diseases are at increased risk for colorectal cancer, but the
molecular mechanisms linking inflammation and cancer are not well defined. We earlier …