Experimental animal models for diabetes and its related complications—a review

CPD Kottaisamy, DS Raj, V Prasanth Kumar… - Laboratory animal …, 2021 - Springer
Diabetes mellitus, a very common and multifaceted metabolic disorder is considered as one
of the fastest growing public health problems in the world. It is characterized by …

Challenges and issues with streptozotocin-induced diabetes–a clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics

SN Goyal, NM Reddy, KR Patil, KT Nakhate… - Chemico-biological …, 2016 - Elsevier
Streptozotocin (STZ) has been extensively used over the last three decades to induce
diabetes in various animal species and to help screen for hypoglycemic drugs. STZ induces …

Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing

Y Jiang, AA Trotsyuk, S Niu, D Henn, K Chen… - Nature …, 2023 - nature.com
Abstract 'Smart'bandages based on multimodal wearable devices could enable real-time
physiological monitoring and active intervention to promote healing of chronic wounds …

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review

K Kolczynska, A Loza-Valdes, I Hawro… - Lipids in health and …, 2020 - Springer
Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol
(DAG) generated in the different cellular compartments in various physiological processes …

Chronic wound healing models

K Flynn, NN Mahmoud, S Sharifi, LJ Gould… - ACS Pharmacology & …, 2023 - ACS Publications
In this paper, we review and analyze the commonly available wound healing models
reported in the literature and discuss their advantages and issues, considering their …

Sources and implications of NADH/NAD+ redox imbalance in diabetes and its complications

J Wu, Z Jin, H Zheng, LJ Yan - Diabetes, metabolic syndrome and …, 2016 - Taylor & Francis
NAD+ is a fundamental molecule in metabolism and redox signaling. In diabetes and its
complications, the balance between NADH and NAD+ can be severely perturbed. On one …

Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes

M Yu, D Agarwal, L Korutla, CL May, W Wang… - Nature …, 2020 - nature.com
The intrahepatic milieu is inhospitable to intraportal islet allografts,–, limiting their
applicability for the treatment of type 1 diabetes. Although the subcutaneous space …

Animal models for diabetes: understanding the pathogenesis and finding new treatments

A King, J Bowe - Biochemical pharmacology, 2016 - Elsevier
Diabetes mellitus is a lifelong, metabolic disease that is characterised by an inability to
maintain normal glucose homeostasis. There are several different forms of diabetes …

Sargassum fusiforme fucoidan modifies the gut microbiota during alleviation of streptozotocin-induced hyperglycemia in mice

Y Cheng, L Sibusiso, L Hou, H Jiang, P Chen… - International Journal of …, 2019 - Elsevier
Diabetes is a complicated endocrine and metabolic disorder, which has become an
epidemic health issue worldwide. Fucoidan is extensively distributed in the brown algae and …

Elucidation of Molecular Mechanisms of Streptozotocin‐Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin‐5F Pancreatic β‐Cells

AMTA Nahdi, A John, H Raza - Oxidative medicine and cellular …, 2017 - Wiley Online Library
Streptozotocin is a pancreatic beta‐cell‐specific cytotoxin and is widely used to induce
experimental type 1 diabetes in rodent models. The precise molecular mechanism of STZ …