In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Patients with severe uncontrolled asthma have disproportionally high morbidity and
healthcare utilization as compared with their peers with well-controlled disease. Although …

Antecedentes Esta la segunda actualización de una revisión publicada anteriormente en la
Biblioteca Cochrane (2015, primera actualización en 2017). La interleucina 5 (IL‐5) es la …

Allergic asthma is defined as asthma associated with sensitization to aeroallergens, which
leads to asthma symptoms and airway inflammation. Allergic asthma is the most common …

Background Asthma is a respiratory (airway) condition that affects an estimated 300 million
people worldwide and is associated with significant morbidity and mortality. Omalizumab is …

Rationale: For many patients with asthma, allergic airway inflammation is primarily a Th2-
weighted process; however, heterogeneity in patterns of inflammation suggests phenotypic …

Traditionally, asthma and allergic diseases have been defined by broad definitions and
treated with nonspecific medications, including corticosteroids and bronchodilators. There is …

This review focuses on recent clinical and translational discoveries in severe and
uncontrolled asthma that now enable phenotyping and personalized therapies in these …

Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …