Mechanism of ferroptosis and its role in type 2 diabetes mellitus

W Sha, F Hu, Y Xi, Y Chu, S Bu - Journal of diabetes research, 2021 - Wiley Online Library
Ferroptosis is a novel form of nonapoptotic regulated cell death (RCD). It features iron‐
dependent lipid peroxide accumulation accompanied by inadequate redox enzymes …

Selenium, selenoproteins and viral infection

OM Guillin, C Vindry, T Ohlmann, L Chavatte - Nutrients, 2019 - mdpi.com
Reactive oxygen species (ROS) are frequently produced during viral infections. Generation
of these ROS can be both beneficial and detrimental for many cellular functions. When …

Chronic kidney disease as oxidative stress-and inflammatory-mediated cardiovascular disease

A Podkowińska, D Formanowicz - Antioxidants, 2020 - mdpi.com
Generating reactive oxygen species (ROS) is necessary for both physiology and pathology.
An imbalance between endogenous oxidants and antioxidants causes oxidative stress …

Glutathione peroxidases

R Brigelius-Flohé, M Maiorino - … et Biophysica Acta (BBA)-General Subjects, 2013 - Elsevier
BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …

[HTML][HTML] Endothelial dysfunction—a major mediator of diabetic vascular disease

CM Sena, AM Pereira, R Seiça - … et Biophysica Acta (BBA)-molecular basis …, 2013 - Elsevier
The vascular endothelium is a multifunctional organ and is critically involved in modulating
vascular tone and structure. Endothelial cells produce a wide range of factors that also …

Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications

XG Lei, JH Zhu, WH Cheng, Y Bao… - Physiological …, 2016 - journals.physiology.org
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from
aerobic metabolism, as a result of accidental electron leakage as well as regulated …

Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

E Lubos, J Loscalzo, DE Handy - 2011 - liebertpub.com
Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

CJ Weydert, JJ Cullen - Nature protocols, 2010 - nature.com
Cells contain a large number of antioxidants to prevent or repair the damage caused by
reactive oxygen species, as well as to regulate redox-sensitive signaling pathways. General …

Cadmium stress: an oxidative challenge

A Cuypers, M Plusquin, T Remans, M Jozefczak… - Biometals, 2010 - Springer
At the cellular level, cadmium (Cd) induces both damaging and repair processes in which
the cellular redox status plays a crucial role. Being not redox-active, Cd is unable to …

Reactive oxygen species, antioxidants, and the mammalian thioredoxin system

J Nordberg, ESJ Arnér - Free radical biology and medicine, 2001 - Elsevier
Reactive oxygen species (ROS) are known mediators of intracellular signaling cascades.
Excessive production of ROS may, however, lead to oxidative stress, loss of cell function …