Trends in carbazole synthesis–an update (2013–2023)

LAT Allen, P Natho - Organic & Biomolecular Chemistry, 2023 - pubs.rsc.org
The interest of scientists in the carbazole core has risen steadily over the last 30 years,
particularly over the last decade given its presence in several active pharmaceutical …

Recent advances in the synthesis of nitrogen heterocycles using arenediazonium salts as nitrogen sources

J Liu, J Jiang, L Zheng, ZQ Liu - Advanced Synthesis & …, 2020 - Wiley Online Library
Nitrogen heterocycles are important structural subunits that occur widely in bioactive natural
products, pharmaceuticals, agrochemicals, dyes, cosmetics, and functional materials …

Recent approaches to the synthesis of tetrahydrocarbazoles

TY Chaudhari, V Tandon - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
The tetrahydrocarbazole (THC) motif is ubiquitous in natural products and biologically active
compounds. THCs can serve as favorable synthetic intermediates or precursors en-route to …

Electrosynthesis of Highly Functionalized Polycyclic N-Heteroaromatics through Cascade Radical Cyclization and Alkoxylation in Batch and Continuous-Flow

J Chen, Y Qiao, W Guan, C Yuan, Y Yao… - ACS Sustainable …, 2023 - ACS Publications
Electrochemical radical cascade cyclization has been recognized as a powerful,
straightforward, and environmentally-friendly synthetic tool to give highly functionalized …

Brønsted Acid-Catalyzed Synthesis of 4-Functionalized Tetrahydrocarbazol-1-ones from 1, 4-Dicarbonylindole Derivatives

S Gómez-Gil, M Solas, S Suárez-Pantiga… - The Journal of Organic …, 2023 - ACS Publications
A p-toluenesulfonic acid-catalyzed cascade reaction is reported for the synthesis of 4-
functionalized tetrahydrocarbazolones via the reaction of 4-(indol-2-yl)-4-oxobutanal …

Recent synthetic strategies for the construction of functionalized carbazoles and their heterocyclic motifs enabled by Lewis acids

MP Kumar, G Mahantesh, P Amaladass… - RSC …, 2023 - pubs.rsc.org
This article demonstrates recent innovative cascade annulation methods for preparing
functionalized carbazoles and their related polyaromatic heterocyclic compounds enabled …

The Borsche–Drechsel (BD) cyclization: Synthesis of tetrahydrocarbazoles and carbazole alkaloids

R Ali - Tetrahedron, 2023 - Elsevier
Abstract The Borsche–Drechsel (BD) cyclization can be treated as a 'special case'of a very
well-known Fischer indole synthesis or so-called Fischer indolization (FI), now and then. To …

Anticancer and immunomodulatory activities of a novel water-soluble derivative of ellipticine

R Costa de Oliveira, G Soares Pontes, A Kostyuk… - Molecules, 2020 - mdpi.com
Cancer still remains a major public health concern around the world and the search for new
potential antitumor molecules is essential for fighting the disease. This study evaluated the …

Synthesis of α-enaminones from cyclic ketones and anilines using oxoammonium salt as an oxygen transfer reagent

B Xu, Y Shang, X Jie, X Zhang, J Kan, SL Yedage… - Green …, 2020 - pubs.rsc.org
A convenient and straightforward transformation of cyclic ketones with anilines at room
temperature has been developed using oxoammonium salt TEMPO+ PF6− as an oxidant …

Regioselection Switch in Nucleophilic Addition to Isoquinolinequinones: Mechanism and Origin of the Regioselectivity in the Total Synthesis of Ellipticine

JAM Castro, BK Serikava, CRS Maior… - The Journal of …, 2022 - ACS Publications
Ellipticine was synthesized in six steps and 20% global yield starting from the readily
available 2, 5-dimethoxy isoquinoline. Unprecedented regioselective control of the …