Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of
muscle loss, this regeneration needs interventional support. Consequently, muscle injury …

Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide
variety of innate and adaptive immune cells orchestrate the complex process of muscle …

Volumetric muscle loss (VML) is a devastating loss of muscle tissue that overwhelms the
native regenerative properties of skeletal muscle and results in lifelong functional deficits …

Millions of Americans suffer from skeletal muscle injuries annually that can result in
volumetric muscle loss (VML), where extensive musculoskeletal damage and tissue loss …

Reconstructive surgery remains inadequate for the treatment of volumetric muscle loss
(VML). The geometry of skeletal muscle defects in VML injuries varies on a case-by-case …

Skeletal muscle has an inherent capacity for spontaneous regeneration. However, recovery
after severe injuries such as volumetric muscle loss (VML) is limited. There is therefore a …

Volumetric muscle loss (VML) injuries are prevalent in civilian and military trauma patients
and are known to impart chronic functional deficits. The frank loss of muscle tissue that …

Musculoskeletal disorders are common in clinical practice. Repairing critical-sized defects in
musculoskeletal systems remains a challenge for researchers and surgeons, requiring the …

Significance: Macrophages are crucial for tissue homeostasis. Based on their activation,
they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro …

Extracellular matrix (ECM) derived scaffolds continue to be investigated for the treatment of
volumetric muscle loss (VML) injuries. Clinically, ECM scaffolds have been used for lower …