[HTML][HTML] Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome

R Lv, X Liu, Y Zhang, N Dong, X Wang, Y He… - Signal transduction and …, 2023 - nature.com
Obstructive sleep apnea syndrome (OSAS) is a common breathing disorder in sleep in
which the airways narrow or collapse during sleep, causing obstructive sleep apnea. The …

Obstructive sleep apnea syndrome and metabolic diseases

M Li, X Li, Y Lu - Endocrinology, 2018 - academic.oup.com
With the rapid changes in lifestyle in modern society, including the high nutritional intake
and reduced physical activity, the incidence of metabolic diseases has been increasing year …

Chronic intermittent hypoxia and obstructive sleep apnea: an experimental and clinical approach

E Sforza, F Roche - Hypoxia, 2016 - Taylor & Francis
Obstructive sleep apnea (OSA) is a prevalent sleep disorder considered as an independent
risk factor for cardiovascular consequences, such as systemic arterial hypertension …

Mechanisms of microglial activation in models of inflammation and hypoxia: Implications for chronic intermittent hypoxia

EA Kiernan, SMC Smith, GS Mitchell… - The Journal of …, 2016 - Wiley Online Library
Chronic intermittent hypoxia (CIH) is a hallmark of sleep apnoea, a condition associated with
diverse clinical disorders. CIH and sleep apnoea are characterized by increased reactive …

[HTML][HTML] A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring

AM Vanderplow, BA Kermath, CR Bernhardt… - PLoS …, 2022 - journals.plos.org
Mounting epidemiologic and scientific evidence indicates that many psychiatric disorders
originate from a complex interplay between genetics and early life experiences, particularly …

[HTML][HTML] Obstructive sleep apnea as an acceleration trigger of cellular senescence processes through telomere shortening

S Turkiewicz, M Ditmer, M Sochal… - International Journal of …, 2021 - mdpi.com
Obstructive sleep apnea (OSA) is chronic disorder which is characterized by recurrent
pauses of breathing during sleep which leads to hypoxia and its two main pathological …

Epigenetic changes by DNA methylation in chronic and intermittent hypoxia

J Nanduri, GL Semenza… - American Journal of …, 2017 - journals.physiology.org
DNA methylation of cytosine residues is a well-studied epigenetic change, which regulates
gene transcription by altering accessibility for transcription factors. Hypoxia is a pervasive …

[HTML][HTML] The impact of genetic variations in ADORA2A in the association between caffeine consumption and sleep

M Erblang, C Drogou, D Gomez-Merino, A Metlaine… - Genes, 2019 - mdpi.com
ADORA2A has been shown to be responsible for the wakefulness-promoting effect of
caffeine and the 1976T> C genotype (SNP rs5751876, formerly 1083T> C) to contribute to …

[HTML][HTML] Overexpression of Foxc1 ameliorates sepsis‑associated encephalopathy by inhibiting microglial migration and neuroinflammation through the IκBα/NF‑κB …

H Wang, H Wang, Y Song, C Liu… - Molecular …, 2022 - spandidos-publications.com
Sepsis‑associated encephalopathy (SAE) is a common and severe complication of sepsis.
The cognitive dysfunction that ensues during SAE has been reported to be caused by …

[HTML][HTML] Intermittent Hypoxia Up-Regulates CCL2, RETN, and TNFα mRNAs in Adipocytes via Down-regulation of miR-452

T Uchiyama, A Itaya-Hironaka, A Yamauchi… - International Journal of …, 2019 - mdpi.com
Sleep apnea syndrome (SAS), characterized by recurrent episodes of oxygen desaturation
and reoxygenation (intermittent hypoxia [IH]), is a risk factor for insulin resistance. Recently …