DNA mismatch repair (MMR) corrects non-Watson-Crick basepairs generated by replication
errors, recombination intermediates, and some forms of chemical damage to DNA. In MutS …

DNA mismatch repair (MMR) requires coordinated sequential actions of multiple proteins
during a window of time after the replication apparatus makes an error and before the newly …

Abstract The bacterial RecF, RecO, and RecR proteins are an epistasis group involved in
loading RecA protein into post-replication gaps. However, the targeting mechanism that …

Bacterial chromosome replication is mainly catalyzed by DNA polymerase III, whose beta
subunits enable rapid processive DNA replication. Enabled by the clamp-loading complex …

Griselimycin, a cyclic depsidecapeptide produced by Streptomyces griseus, is a promising
lead inhibitor of the sliding clamp component of bacterial DNA polymerases (β-subunit of …

DNA mismatch repair endonuclease MutL binds two zinc ions. However, the endonuclease
activity of MutL is drastically enhanced by other divalent metals such as manganese …

DNA replication is a tightly coordinated event carried out by a multiprotein replication
complex. An essential factor in the bacterial replication complex is the ring-shaped DNA …

As no crystal structure of full-size MutL bound to DNA has been obtained up to date, in the
present work we used crosslinking and Förster resonance energy transfer (FRET) assays for …

Repeat-mediated deletions (RMDs) are a type of deletion rearrangement that utilizes two
repetitive elements to bridge a DNA double-strand break (DSB) that leads to loss of the …

The DNA mismatch repair (MMR) process detects and corrects replication errors in
organisms ranging from bacteria to humans. In most bacteria, it is initiated by MutS detecting …