Background Congenital disorders of glycosylation (CDG) are inherited metabolic diseases
caused by defects in the genes important for the process of protein and lipid glycosylation …

The majority of human proteins operate as multimeric complexes with defined compositions
and distinct architectures. How the assembly of these complexes is surveyed and how …

The fusion of transport vesicles with their target membranes is fundamental for intracellular
membrane trafficking and diverse physiological processes and is driven by the assembly of …

Membrane trafficking pathways are essential for the viability and growth of cells, and play a
major role in the interaction of cells with their environment. In this At a Glance article and …

We identified loss-of-function mutations in ATP6V0A2, encoding the a2 subunit of the V-type
H+ ATPase, in several families with autosomal recessive cutis laxa type II or wrinkly skin …

Glycosylation is a ubiquitous modification that occurs on proteins and lipids in all living cells.
Consistent with their high complexity, glycans play crucial biological roles in protein quality …

Protein glycosylation is a complex process that depends not only on the activities of several
enzymes and transporters but also on a subtle balance between vesicular Golgi trafficking …

Congenital disorders of glycosylation comprise most of the nearly 70 genetic disorders
known to be caused by impaired synthesis of glycoconjugates. The effects are expressed in …

Protein traffic is necessary to maintain homeostasis in all eukaryotic organisms. All newly
synthesized secretory proteins destined to the secretory and endolysosmal systems are …

The conserved oligomeric Golgi (COG) complex, a multisubunit tethering complex of the
CATCHR (complexes associated with tethering containing helical rods) family, controls …