[HTML][HTML] Antioxidant response elements: Discovery, classes, regulation and potential applications
Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …
encoding antioxidant proteins, detoxifying enzymes, and xenobiotic transporters to offer …
Stress-activated cap'n'collar transcription factors in aging and human disease
GP Sykiotis, D Bohmann - Science signaling, 2010 - science.org
Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …
Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway
The cap'n'collar (CNC) bZIP transcription factor Nrf2 controls expression of genes for
antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes, drug transporters …
antioxidant enzymes, metal-binding proteins, drug-metabolising enzymes, drug transporters …
Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop
J Steffen, M Seeger, A Koch, E Krüger - Molecular cell, 2010 - cell.com
Coordinated regulation of the ubiquitin-proteasome system (UPS) is crucial for the cell to
adjust its protein degradation capacity to changing proteolytic requirements. We have shown …
adjust its protein degradation capacity to changing proteolytic requirements. We have shown …
Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
M Biswas, JY Chan - Toxicology and applied pharmacology, 2010 - Elsevier
Oxidative stress plays an important part in the pathogenesis of a variety of diseases. The
ability to mount an efficient response against the continuous threat posed by exogenous and …
ability to mount an efficient response against the continuous threat posed by exogenous and …
Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf
KM Glover-Cutter, S Lin, TK Blackwell - PLoS genetics, 2013 - journals.plos.org
The Unfolded Protein Response (UPR) maintains homeostasis in the endoplasmic reticulum
(ER) and defends against ER stress, an underlying factor in various human diseases. During …
(ER) and defends against ER stress, an underlying factor in various human diseases. During …
Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity
Y Zhang, Y Xiang - Biochemical Journal, 2016 - portlandpress.com
The consensus cis-regulatory AP-1 (activator protein-1)-like AREs (antioxidant-response
elements) and/or EpREs (electrophile-response elements) allow for differential recruitment …
elements) and/or EpREs (electrophile-response elements) allow for differential recruitment …
Nuclear factor erythroid-2 like 1 (NFE2L1): structure, function and regulation
Nrf1 (also referred to as NFE2L1) is a member of the CNC-bZIP family of transcription factors
that are characterized by a highly conserved CNC-domain, and a basic-leucine zipper …
that are characterized by a highly conserved CNC-domain, and a basic-leucine zipper …
Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy
The endoplasmic reticulum (ER) lumen is chemically complex and crowded with
polypeptides in different stages of assembly. ER quality control monitors chaperone-assisted …
polypeptides in different stages of assembly. ER quality control monitors chaperone-assisted …
[HTML][HTML] Unravelling the role of NFE2L1 in stress responses and related diseases
X Liu, C Xu, W Xiao, N Yan - Redox Biology, 2023 - Elsevier
The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …