Post-transcriptional gene regulation: from genome-wide studies to principles
RE Halbeisen, A Galgano, T Scherrer… - Cellular and molecular life …, 2008 - Springer
Post-transcriptional regulation of gene expression plays important roles in diverse cellular
processes such as development, metabolism and cancer progression. Whereas many …
processes such as development, metabolism and cancer progression. Whereas many …
[HTML][HTML] Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer
The complex interactions between tumors and their microenvironment remain to be
elucidated. Combining large-scale approaches, we examined the spatio-temporal dynamics …
elucidated. Combining large-scale approaches, we examined the spatio-temporal dynamics …
Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes
D Castel, C Philippe, R Calmon, L Le Dret… - Acta …, 2015 - Springer
Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no
significant therapeutic progress made in the past 50 years. Recent studies suggest that …
significant therapeutic progress made in the past 50 years. Recent studies suggest that …
Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
Background While large-scale cancer genomic projects are comprehensively characterizing
the mutational spectrum of various cancers, so far little attention has been devoted to either …
the mutational spectrum of various cancers, so far little attention has been devoted to either …
Regulation of phosphatidylethanolamine homeostasis—the critical role of CTP: phosphoethanolamine cytidylyltransferase (Pcyt2)
Z Pavlovic, M Bakovic - International journal of molecular sciences, 2013 - mdpi.com
Phosphatidylethanolamine (PE) is the most abundant lipid on the protoplasmatic leaflet of
cellular membranes. It has a pivotal role in cellular processes such as membrane fusion, cell …
cellular membranes. It has a pivotal role in cellular processes such as membrane fusion, cell …
Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer
GM Arndt, L Dossey, LM Cullen, A Lai, R Druker… - BMC cancer, 2009 - Springer
Abstract Background MicroRNAs (MiRNAs) are short non-coding RNAs that control protein
expression through various mechanisms. Their altered expression has been shown to be …
expression through various mechanisms. Their altered expression has been shown to be …
Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G 1 cyclins/cyclin‐dependent kinases and the phosphoinositide 3‐kinase/AKT …
Increasing evidence suggests that PRMT 5, a protein arginine methyltransferase, is involved
in tumorigenesis. However, no systematic research has demonstrated the cell‐transforming …
in tumorigenesis. However, no systematic research has demonstrated the cell‐transforming …
SOX2-OT induced by PAI-1 promotes triple-negative breast cancer cells metastasis by sponging miR-942-5p and activating PI3K/Akt signaling
W Zhang, S Yang, D Chen, D Yuwen, J Zhang… - Cellular and Molecular …, 2022 - Springer
Triple-negative breast cancer (TNBC) has an aggressive biological behavior and poor
outcome. Our published study showed that PAI-1 could induce the migration and metastasis …
outcome. Our published study showed that PAI-1 could induce the migration and metastasis …
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells
S White-Gilbertson, T Mullen, C Senkal, P Lu… - Oncogene, 2009 - nature.com
We have previously shown that the death receptor ligand TRAIL (tumor necrosis factor-
related apoptosis-inducing ligand) induces an increase of intracellular C 16-ceramide in …
related apoptosis-inducing ligand) induces an increase of intracellular C 16-ceramide in …
A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers
Successful tumor development and progression involves the complex interplay of both pro-
and anti-oncogenic signaling pathways. Genetic components balancing these opposing …
and anti-oncogenic signaling pathways. Genetic components balancing these opposing …