Immune checkpoint inhibitors have emerged as a remarkable treatment option for diverse
cancer types. However, a significant number of patients on checkpoint inhibitors develop …

After a century of controversy, the notion that the immune system regulates cancer
development is experiencing a new resurgence. An overwhelming amount of data from …

The discovery of disorders that are associated with antibodies to neuronal cell-surface
proteins has led to a paradigm shift in our understanding of CNS autoimmunity. These …

Paraneoplastic Syndromes Involving the Nervous System | New England Journal of Medicine
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We reviewed 200 patients with paraneoplastic encephalomyelitis (PEM) and anti-Hu
antibodies to show possible clinical differences with respect to previous series, and to …

HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal
posttranscriptional regulator of gene expression. Here, HuR was immunoprecipitated under …

Paraneoplastic neurological syndromes (PNS) are the immune-mediated effects of a remote
cancer and are characterised by an autoantibody response against antigens expressed by …

Type 1 antineuronal nuclear autoantibody (ANNA-1, also known as" anti-Hu") is a marker of
neurologic autoimmunity that is highly associated with small-cell lung carcinoma (SCLC). To …

Cancer treatment strategies based on immune stimulation have recently entered the clinical
arena, with unprecedented success. Immune checkpoint inhibitors (ICIs) work by …

Colorectal carcinoma RKO cells expressing reduced levels of the RNA‐binding protein HuR
(ASHuR) displayed markedly reduced growth. In synchronous RKO populations, HuR was …