Background Implementing treatments and interventions with demonstrated effectiveness is
critical for improving patient health outcomes at a reduced cost. When an evidence-based …

Abstract Background and objective The Learning Healthcare System paradigm has attracted
the attention of researchers worldwide. The great potential originating from high-scale health …

Background Interest in value-based healthcare, generally defined as providing better care at
lower cost, has grown worldwide, and learning health systems (LHSs) have been proposed …

This is the introductory paper in a series of eight papers. In this series, we integrate the
theoretical design options with the practice of conducting pragmatic trials. For most new …

Profound global challenges to individual and population health, alongside the opportunities
to benefit from digital technology, have spawned the concept of the Learning Health System …

The semantic web is an emerging technology that helps to connect different users to create
their content and also facilitates the way of representing information in a manner that can be …

The benefits of reusing EHR data for clinical research studies are numerous. They portend
the opportunity to bring new therapies to patients sooner, potentially at a lower cost, and to …

Objectives To examine variations across general practices and factors associated with
antibiotic prescribing for common infections in UK primary care to identify potential targets …

In recent years, health systems across the United States and around the world have faced
persistent challenges including the underutilization of necessary care, the overutilization of …

With the emergence of electronic health records, the reuse of clinical data offers new
perspectives for the diagnosis and management of patients with rare diseases. However …