Human APOBEC3 variations and viral infection
S Sadeghpour, S Khodaee, M Rahnama, H Rahimi… - Viruses, 2021 - mdpi.com
Human APOBEC3 (apolipoprotein B mRNA-editing catalytic polypeptide-like 3) enzymes
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
are capable of inhibiting a wide range of endogenous and exogenous viruses using …
The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities
AM Green, MD Weitzman - DNA repair, 2019 - Elsevier
The APOBEC3 family of cytosine deaminases are part of the innate immune response to
viral infection, but also have the capacity to damage cellular DNA. Detection of mutational …
viral infection, but also have the capacity to damage cellular DNA. Detection of mutational …
Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases
The human APOBEC family of eleven cytosine deaminases use RNA and single-stranded
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
DNA (ssDNA) as substrates to deaminate cytosine to uracil. This deamination event has …
Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure
YZ McDaniel, D Wang, RP Love… - Nucleic acids …, 2020 - academic.oup.com
The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3,
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
The role of APOBECs in viral replication
WK Xu, H Byun, JP Dudley - Microorganisms, 2020 - mdpi.com
Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC) proteins are a
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
diverse and evolutionarily conserved family of cytidine deaminases that provide a variety of …
Predicting mammalian species at risk of being infected by SARS-CoV-2 from an ACE2 perspective
SARS-CoV-2 can transmit efficiently in humans, but it is less clear which other mammals are
at risk of being infected. SARS-CoV-2 encodes a Spike (S) protein that binds to human …
at risk of being infected. SARS-CoV-2 encodes a Spike (S) protein that binds to human …
The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead
M Granadillo Rodriguez, B Flath… - Open Biology, 2020 - royalsocietypublishing.org
Cancer is considered a group of diseases characterized by uncontrolled growth and spread
of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing …
of abnormal cells and is propelled by somatic mutations. Apolipoprotein B mRNA-editing …
Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
A single cancer genome can harbor thousands of clustered mutations. Mutation signature
analyses have revealed that the origin of clusters are lesions in long tracts of single …
analyses have revealed that the origin of clusters are lesions in long tracts of single …
Replication catastrophe induced by cyclic hypoxia leads to increased APOBEC3B activity
Tumor heterogeneity includes variable and fluctuating oxygen concentrations, which result
in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to …
in the accumulation of hypoxic regions in most solid tumors. Tumor hypoxia leads to …
Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function
GM Jang, AKA Sudarsan, A Shayeganmehr… - Molecular & Cellular …, 2024 - ASBMB
Human APOBEC3 enzymes are a family of single-stranded (ss) DNA and RNA cytidine
deaminases that act as part of the intrinsic immunity against viruses and retroelements …
deaminases that act as part of the intrinsic immunity against viruses and retroelements …