Naturally fluorescent proteins have revolutionized biology by enabling what was formerly
invisible to be seen clearly. These proteins have allowed us to visualize, in real time …

Matrix metalloproteinases (MMPs) are a family of zinc endopeptidases that cleave nearly all
components of the extracellular matrix as well as many other soluble and cell‐associated …

Members of the matrix metalloproteinase (MMP) family have been identified as poor
prognosis markers for breast cancer patients and as drivers of many facets of the tumor …

Membrane-type matrix metalloproteases (MT-MMP) are pivotal regulators of cell invasion,
growth and survival. Tethered to the cell membranes by a transmembrane domain or GPI …

Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic
agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we …

Tissue regeneration after injury requires coordinated regulation of stem cell activation,
division, and daughter cell differentiation, processes that are increasingly well understood in …

Among the various advantages of aptamers over antibodies, remarkable is their ability to
tolerate a large number of chemical modifications within their backbone or at the termini …

The presence of sarcomatoid features in clear cell renal cell carcinoma (ccRCC) confers a
poor prognosis and is of unknown pathogenesis. We performed exome sequencing of …

Intracellular localization has been reported for over three‐quarters of receptor tyrosine
kinase (RTK) families in response to environmental stimuli. Internalized RTK may bind to …

Understanding the physiological role of any protease requires identification of both its
cleavage substrates and their relative cleavage efficacy as compared with other substrates …