[HTML][HTML] Lipids and Alzheimer's disease

YC Kao, PC Ho, YK Tu, IM Jou, KJ Tsai - International journal of molecular …, 2020 - mdpi.com
Lipids, as the basic component of cell membranes, play an important role in human health
as well as brain function. The brain is highly enriched in lipids, and disruption of lipid …

Sphingolipids: membrane microdomains in brain development, function and neurological diseases

ASB Olsen, NJ Færgeman - Open biology, 2017 - royalsocietypublishing.org
Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

The prebiotics 3′ Sialyllactose and 6′ Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the …

AJ Tarr, JD Galley, SE Fisher, M Chichlowski… - Brain, behavior, and …, 2015 - Elsevier
There are extensive bidirectional interactions between the gut microbiota and the central
nervous system (CNS), and studies demonstrate that stressor exposure significantly alters …

[HTML][HTML] The role of gangliosides in neurodevelopment

K Palmano, A Rowan, R Guillermo, J Guan… - Nutrients, 2015 - mdpi.com
Gangliosides are important components of neuronal cell membranes and it is widely
accepted that they play a critical role in neuronal and brain development. They are …

Sphingolipid control of cognitive functions in health and disease

LS Kalinichenko, E Gulbins, J Kornhuber… - Progress in Lipid …, 2022 - Elsevier
Cognitive processes, particularly learning and memory, are crucial brain mechanisms
mediating the successful adaptation of individuals to constantly changing environmental …

Gangliosides of the nervous system

R Ledeen, G Wu - Gangliosides: Methods and Protocols, 2018 - Springer
This review begins by attempting to recount some of the pioneering discoveries that first
identified the presence of gangliosides in the nervous system, their structures and …

Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats

E Oliveros, M Ramirez, E Vazquez, A Barranco… - The Journal of nutritional …, 2016 - Elsevier
Human milk oligosaccharides have been proposed to exert beneficial effects on brain
development. During the last decades, most of the studies have focused on the evaluation of …

[HTML][HTML] APP function and lipids: a bidirectional link

MOW Grimm, J Mett, HS Grimm… - Frontiers in molecular …, 2017 - frontiersin.org
Extracellular neuritic plaques, composed of aggregated amyloid-β (Aβ) peptides, are one of
the major histopathological hallmarks of Alzheimer's disease (AD), a progressive …

[HTML][HTML] Intranasal infusion of GD3 and GM1 gangliosides downregulates alpha-synuclein and controls tyrosine hydroxylase gene in a PD model mouse

Y Itokazu, T Fuchigami, JC Morgan, KY Robert - Molecular Therapy, 2021 - cell.com
Parkinson's disease (PD) is characterized by Lewy bodies (composed predominantly of
alpha-synuclein [aSyn]) and loss of pigmented midbrain dopaminergic neurons comprising …

Restoration of adult neurogenesis by intranasal administration of gangliosides GD3 and GM1 in the olfactory bulb of A53T alpha-synuclein-expressing Parkinson's …

T Fuchigami, Y Itokazu, JC Morgan, RK Yu - Molecular neurobiology, 2023 - Springer
Parkinson's disease (PD) is the second most common neurodegenerative disorder affecting
the body and mind of millions of people in the world. As PD progresses, bradykinesia …