Alkoxy radicals are highly reactive species that have long been recognized as versatile
intermediates in organic synthesis. However, their development has long been impeded due …

As a result of the adaptation of life to an aerobic environment, nature has evolved a panoply
of metalloproteins for oxidative metabolism and protection against reactive oxygen species …

The intermediacy of alkoxy radicals in cerium-catalyzed C–H functionalization via H-atom
abstraction has been unambiguously confirmed. Catalytically relevant Ce (IV)–alkoxide …

The direct functionalization of C (sp3)–H bonds represents one of the most investigated
approaches to develop new synthetic methodology. Among the available strategies for …

Radical reactivity is a powerful tool for molecular construction that often provides bond-
forming strategies and retrosynthetic disconnections complementary to those available …

Modern photoredox catalysis has traditionally relied upon metal-to-ligand charge-transfer
(MLCT) excitation of metal polypyridyl complexes for the utilization of light energy for the …

Primary aliphatic amines are important building blocks in organic synthesis due to the
presence of a synthetically versatile NH2 group. N-functionalization of primary amines is …

Conventional hydrofunctionalization of α-olefins with mineral acids proceeds with
Markovnikov selectivity to afford branched isomers. The direct formation of linear …

The generation of azide radical (N3˙) occurs from its precursors primarily via a single
electron transfer (SET) process or homolytic cleavage by chemical methods or advanced …

In the future, standard procedures for chemical processes should require only inexpensive
reagents used in standard equipment under the mildest possible conditions, and they …