Targeting macrophage autophagy for inflammation resolution and tissue repair in inflammatory bowel disease

E Wang, MY Wu, Z Ren, Y Zheng, RD Ye… - Burns & …, 2023 - academic.oup.com
Inflammatory bowel disease (IBD) is a chronic, non-specific, recurrent inflammatory disease,
majorly affecting the gastrointestinal tract. Due to its unclear pathogenesis, the current …

[HTML][HTML] The Eph/ephrin system symphony of gut inflammation

P Qiu, D Li, C Xiao, F Xu, X Chen, Y Chang… - Pharmacological …, 2023 - Elsevier
The extent of gut inflammation depends largely on the gut barrier's integrity and enteric
neuroimmune interactions. However, the factors and molecular mechanisms that regulate …

Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation

H Sang, W Zhang, L Peng, S Wei, X Zhu, K Huang… - Cell Death & …, 2022 - nature.com
Circular RNAs (circRNAs) play a vital role in the occurrence and development of tumors,
including gastric cancer (GC). However, there are still many circRNAs related to GC whose …

Baitouweng decoction repairs the intestinal barrier in DSS-induced colitis mice via regulation of AMPK/mTOR-mediated autophagy

SM Pan, CL Wang, ZF Hu, ML Zhang, ZF Pan… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ulcerative colitis (UC) is one of non-specific inflammatory
bowel disease that mainly affects the colon. Recently, UC has become a significant social …

Laminar shear stress inhibits inflammation by activating autophagy in human aortic endothelial cells through HMGB1 nuclear translocation

Q Meng, L Pu, M Qi, S Li, B Sun, Y Wang… - Communications …, 2022 - nature.com
Prevention and treatment of atherosclerosis (AS) by targeting the inflammatory response in
vascular endothelial cells has attracted much attention in recent years. Laminar shear stress …

SNRK modulates mTOR-autophagy pathway for liver lipid homeostasis in MAFLD

S Lin, X Qiu, X Fu, S Zhang, C Tang, J Kuang, H Guan… - Molecular Therapy, 2025 - cell.com
Metabolism-related fatty liver disease (MAFLD) is associated with abnormal fat accumulation
in the liver. The exact mechanism underlying the occurrence and development of MAFLD …

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

K Ranjan, M Hedl, S Sinha, X Zhang… - The Journal of …, 2021 - Am Soc Clin Investig
Properly balancing microbial responses by the innate immune system through pattern
recognition receptors (PRRs) is critical for intestinal immune homeostasis. Ring finger …

[HTML][HTML] Activation of P2Y1R impedes intestinal mucosa repair during colitis

Q Huan, J Peng, Y Chang, Q Zhang, T Xing… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Delayed intestinal mucosal healing is one of the pathogenic bases for the recurrence of
inflammatory bowel disease (IBD), but how the IBD inflammatory environment impedes …

Caveolin-1 alleviates Crohn's disease–induced intestinal fibrosis by inhibiting fibroblasts autophagy through modulating sequestosome 1

M Yu, W Zhu, J Wang, X Chen, X He… - Inflammatory bowel …, 2022 - academic.oup.com
Background Intestinal fibrosis is a common complication of Crohn's disease (CD) and is
characterized by the excessive accumulation of extracellular matrix produced by activated …

Polysaccharide from Strongylocentrotus nudus eggs regulates intestinal epithelial autophagy through CD36/PI3K-Akt pathway to ameliorate inflammatory bowel …

M Zhou, J Zhi, J Zhi, Z Xiong, F Wu, Y Lu… - International Journal of …, 2023 - Elsevier
Sea urchin is a popular food all over the world, of which eggs are main edible part. Previous
studies suggested that polysaccharides from eggs of Strongylocentrotus nudus (SEP) …