A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

Cardiovascular disease (CVD) remains the most common cause of death worldwide and
has become a public health concern. The proven notable risk factors for CVD are …

Background: The gut microbiota-dependent metabolite phenylacetylgutamine (PAGln) is
both associated with atherothrombotic heart disease in humans, and mechanistically linked …

Heart failure is a worldwide health problem with important consequences for the overall
wellbeing of affected individuals as well as for the healthcare system. Over recent decades …

Fibers remain undigested until they reach the colon, where some are fermented by gut
microbiota, producing metabolites called short-chain fatty acids (SCFAs), such as acetate …

Heart failure (HF) is marked by distinctive changes in myocardial uptake and utilization of
energy substrates. Among the different types of HF, HF with preserved ejection fraction …

Metformin has been in clinical use for the management of type 2 diabetes for more than 60
years and is supported by a vast database of clinical experience: this includes evidence for …

Recent evidence supports a role for the gut microbiota in hypertension, but whether
ambulatory blood pressure is associated with gut microbiota and their metabolites remains …

Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

Aims Studies have linked gut microbiome and heart failure (HF). However, their causal
relationships and potential mediating factors have not been well defined. To investigate the …