Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell
surface proteins. GPIs in various organisms have a common backbone consisting of …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

In the early days of epithelial cell biology, researchers working with kidney and/or intestinal
epithelial cell lines and with hepatocytes described the biosynthetic and recycling routes …

Polarized intracellular trafficking in epithelia is critical in development, immunity, and
physiology to deliver morphogens, defensins, or ion pumps to the appropriate membrane …

Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved post-translational
modification in eukaryotes. GPI is synthesized and transferred to proteins in the endoplasmic …

Abstract Glycosylphosphatidylinositol (GPI)-anchored proteins (GPI-APs) are a class of
membrane proteins containing a soluble protein attached by a conserved glycolipid anchor …

Oxysterol binding protein (OSBP) extracts cholesterol from the ER to deliver it to the TGN via
counter exchange and subsequent hydrolysis of the phosphoinositide PI (4) P. Here, we …

The epithelial Na+ channel (ENaC) is a major regulator of salt and water reabsorption in a
number of epithelial tissues. Abnormalities in ENaC function have been directly linked to …

The vitamin folic acid has been recognized as a crucial environmental factor for nervous
system development. From the early fetal stages of the formation of the presumptive spinal …