The promise of nicotinic receptors as a therapeutic target has yet to be fully realized, despite
solid data supporting their involvement in neurological and neuropsychiatric diseases. The …

The cholinergic system modulates many biological functions, due to the widespread
distribution of cholinergic neuronal terminals, and the diffuse release of its neurotransmitter …

CRISPR/Cas9-mediated genome editing technology enables researchers to efficiently
generate and analyze genetically modified animals. We have taken advantage of this game …

Lypd6 is a GPI-tethered protein from the Ly-6/uPAR family expressed in the brain. Lypd6
enhances the Wnt/β-catenin signaling, although its action on nicotinic acetylcholine …

Intellectual disability and autistic features are associated with chromosome region 2q23.
q23. 2 duplication carrying LYPD6 and LYPD6B genes. Here, we analyzed LYPD6 and …

Ly-6/uPAR or three-finger proteins (TFPs) contain a disulfide-stabilized β-structural core and
three protruding loops (fingers). In mammals, TFPs have been found in epithelium and the …

Ly6/uPAR proteins regulate many essential functions in the nervous and immune systems
and epithelium. Most of these proteins contain single β-structural LU domains with three …

The cholinergic system helps to transduce experiences through the modulation of functional
circuits in the brain. It is a neurotransmitter system implicated in many complex cognitive …

Nicotinic acetylcholine receptors (nAChRs) are the ligand-gated ion channels important for
intercellular signaling. These receptors are abundant in neuromuscular junctions …

The present study investigated the plausible modulatory role of central histaminergic
transmission on the expression of nicotine withdrawal induced anxiety and somatic behavior …