Status and challenges for vaccination against avian H9N2 influenza virus in China

J Dong, Y Zhou, J Pu, L Liu - Life, 2022 - mdpi.com
In China, H9N2 avian influenza virus (AIV) has become widely prevalent in poultry, causing
huge economic losses after secondary infection with other pathogens. Importantly, H9N2 …

Engineering an optimal Y280-lineage H9N2 vaccine strain by tuning PB2 activity

SH An, SM Hong, JH Song, SE Son, CY Lee… - International Journal of …, 2023 - mdpi.com
H9N2 avian influenza A viruses (AIVs) cause economic losses in the poultry industry and
provide internal genomic segments for the evolution of H5N1 and H7N9 AIVs into more …

Bioengineering a highly productive vaccine strain in embryonated chicken eggs and mammals from a non-pathogenic clade 2· 3· 4· 4 H5N8 strain

SH An, CY Lee, SM Hong, JG Choi, YJ Lee, JH Jeong… - Vaccine, 2019 - Elsevier
Abstract The clade 2· 3· 4· 4 H5Nx is a highly pathogenic avian influenza (HPAI) virus, which
first appeared in China and has spread worldwide since then, including Korea. It is divided …

[HTML][HTML] A Model H5N2 Vaccine Strain for Dual Protection Against H5N1 and H9N2 Avian Influenza Viruses

JH Song, SE Son, HW Kim, SH An, CY Lee, HJ Kwon… - Vaccines, 2024 - mdpi.com
Background/Objective: Highly pathogenic (HP) H5Nx and low-pathogenicity (LP) H9N2
avian influenza viruses (AIVs) pose global threats to the poultry industry and public health …

Selection of an optimal recombinant egyptian H9N2 avian influenza vaccine strain for poultry with high antigenicity and safety

SH An, SE Son, JH Song, SM Hong, CY Lee, NH Lee… - Vaccines, 2022 - mdpi.com
For the development of an optimized Egyptian H9N2 vaccine candidate virus for poultry,
various recombinant Egyptian H9N2 viruses generated by a PR8-based reverse genetics …

Improvement of PR8-derived recombinant clade 2.3. 4.4 c H5N6 vaccine strains by optimization of internal genes and H103Y mutation of hemagglutinin

SH An, SM Hong, SE Son, JH Song, CY Lee, JG Choi… - Vaccines, 2020 - mdpi.com
Clade 2.3. 4.4 c H5N6 avian influenza A viruses (AIVs) may have originally adapted to infect
chickens and have caused highly pathogenic avian influenza (HPAI) in poultry and human …

H5N6 recombinant influenza virus, a composition for preparing the same, and a vaccine composition containing the same

HJ Kwon, SH An, SM Hong - US Patent 12,090,199, 2024 - Google Patents
The present invention relates to an mammalian non-pathogenic, highly-productive-in-
embryonated-egg, heat-resistant, and attenuated clade 2.3. 4.4 c H5N6 recombinant …

Development of highly productive and mammalian non-pathogenic recombinant avian influenza vaccine strains

안세희 - 2020 - s-space.snu.ac.kr
Avian influenza viruses (AIVs) are highly infectious pathogen of waterfowls and can
overcome species barriers to infect mammals by acquiring cumulative mutations. Low …