The phospholipase D superfamily as therapeutic targets
MA Frohman - Trends in pharmacological sciences, 2015 - cell.com
The phospholipase D (PLD) lipid-signaling enzyme superfamily has long been studied for its
roles in cell communication and a wide range of cell biological processes. With the advent of …
roles in cell communication and a wide range of cell biological processes. With the advent of …
Mammalian phospholipase D: Function, and therapeutics
Despite being discovered over 60 years ago, the precise role of phospholipase D (PLD) is
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
still being elucidated. PLD enzymes catalyze the hydrolysis of the phosphodiester bond of …
Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2
SK Lee, SD Kim, M Kook, HY Lee, J Ghim… - Journal of Experimental …, 2015 - rupress.org
We determined the function of phospholipase D2 (PLD2) in host defense in highly lethal
mouse models of sepsis using PLD2−/− mice and a PLD2-specific inhibitor. PLD2 deficiency …
mouse models of sepsis using PLD2−/− mice and a PLD2-specific inhibitor. PLD2 deficiency …
[PDF][PDF] Physiological and pathophysiological roles for phospholipase D
RK Nelson, MA Frohman - J Lipid Res, 2015 - researchgate.net
Individual members of the mammalian Phospholipase D (PLD) superfamily undertake roles
that extend from generating the second messenger signaling lipid phosphatidic acid through …
that extend from generating the second messenger signaling lipid phosphatidic acid through …
Phospholipase D2 controls bone homeostasis by modulating M-CSF-dependent osteoclastic cell migration and microtubule stability
HJ Kim, DK Lee, X Jin, X Che, SH Ryu… - Experimental & Molecular …, 2022 - nature.com
Abstract Phospholipase D2 (PLD2), a signaling protein, plays a central role in cellular
communication and various biological processes. Here, we show that PLD2 contributes to …
communication and various biological processes. Here, we show that PLD2 contributes to …
A Critical Analysis of the Available In Vitro and Ex Vivo Methods to Study Retinal Angiogenesis
AF Moleiro, G Conceição… - Journal of …, 2017 - Wiley Online Library
Angiogenesis is a biological process with a central role in retinal diseases. The choice of the
ideal method to study angiogenesis, particularly in the retina, remains a problem …
ideal method to study angiogenesis, particularly in the retina, remains a problem …
[HTML][HTML] Phospholipase D and its essential role in cancer
JH Cho, JS Han - Molecules and cells, 2017 - Elsevier
The role of phospholipase D (PLD) in cancer development and management has been a
major area of interest for researchers. The purpose of this mini-review is to explore PLD and …
major area of interest for researchers. The purpose of this mini-review is to explore PLD and …
Phospholipase D as a key modulator of cancer progression
The phospholipase D (PLD) family has a ubiquitous expression in cells. PLD isoforms
(PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in …
(PLDs) and their hydrolysate phosphatidic acid (PA) have been demonstrated to engage in …
Associations of variants In the hexokinase 1 and interleukin 18 receptor regions with oxyhemoglobin saturation during sleep
Sleep disordered breathing (SDB)-related overnight hypoxemia is associated with
cardiometabolic disease and other comorbidities. Understanding the genetic bases for …
cardiometabolic disease and other comorbidities. Understanding the genetic bases for …
Targeting PLD2 in adipocytes augments adaptive thermogenesis by improving mitochondrial quality and quantity in mice
HS Kim, MY Park, NJ Yun, HS Go, MY Kim… - Journal of Experimental …, 2021 - rupress.org
Phospholipase D (PLD) 2 via its enzymatic activity regulates cell proliferation and migration
and thus is implicated in cancer. However, the role of PLD2 in obesity and type 2 diabetes …
and thus is implicated in cancer. However, the role of PLD2 in obesity and type 2 diabetes …