All life forms sense and respond to mechanical stimuli. Throughout evolution, organisms
develop diverse mechanosensing and mechanotransduction pathways, leading to fast and …

Spatial positioning is a fundamental principle governing nuclear processes. Chromatin is
organized as a hierarchy from nucleosomes to Mbp chromatin domains (CD) or topologically …

Target prediction is generally the first step toward recognition of bona fide microRNA
(miRNA)-target interactions in living cells. Several target prediction tools are now available …

The nucleus is a complex and highly compartmentalized organelle, which undergoes major
organization changes during cell differentiation, allowing cells to become specialized and …

Nuclear bodies contribute to non‐random organization of the human genome and nuclear
function. Using a major prototypical nuclear body, the Cajal body, as an example, we …

In eukaryotic cells, most of the genetic material is contained within a highly specialized
organelle—the nucleus. A large body of evidence indicates that, within the nucleus …

Simple Summary Chromosomal translocations are products of the erroneous repair of DNA
double-strand breaks that result in the illegitimate joining of the two broken chromosomal …

Chromosomes inside the nucleus are not located in the form of linear molecules. Instead,
there is a complex multilevel genome folding that includes nucleosomes packaging …

Background Grading schemes for breast cancer diagnosis are predominantly based on
pathologists' qualitative assessment of altered nuclear structure from 2D brightfield …

The organization of interphase chromosomes in chromosome territories (CTs) was first
proposed more than one hundred years ago. The introduction of increasingly sophisticated …