Carboranes in drug discovery, chemical biology and molecular imaging

A Marfavi, P Kavianpour, LM Rendina - Nature Reviews Chemistry, 2022 - nature.com
There exists a paucity of structural innovation and limited molecular diversity associated with
molecular frameworks in drug discovery and biomolecular imaging/chemical probe design …

The boron advantage: the evolution and diversification of boron's applications in medicinal chemistry

K Messner, B Vuong, GK Tranmer - Pharmaceuticals, 2022 - mdpi.com
In this review, the history of boron's early use in drugs, and the history of the use of boron
functional groups in medicinal chemistry applications are discussed. This includes …

Boron cluster compounds as new chemical leads for antimicrobial therapy

K Fink, M Uchman - Coordination Chemistry Reviews, 2021 - Elsevier
Boron cluster compounds are inorganic compounds with chemical compositions and
structures vastly different from those of organic compounds, albeit with the ability to form a …

Challenges and opportunities for the application of boron clusters in drug design

ZJ Lesnikowski - Journal of medicinal chemistry, 2016 - ACS Publications
There are two branches in boron medicinal chemistry: the first focuses on single boron atom
compounds, and the second utilizes boron clusters. Boron clusters and their heteroatom …

Boron science

NS Hosmane - New technologies and applications, 2011 - api.taylorfrancis.com
What is boron? The question itself may not seem very significant to many people. Their
introduction to the word “boron” could come as the butt of a joke. Conan O'Brien made jokes …

Boron in drug discovery: carboranes as unique pharmacophores in biologically active compounds

F Issa, M Kassiou, LM Rendina - Chemical reviews, 2011 - ACS Publications
Boron, in the form of boric acid, has played a role in medicine as a mild antiseptic and an
eye wash since its preparation from borax in the 18th century. However, the use of boron in …

Supramolecular chemistry of anionic boron clusters and its applications in biology

J Cebula, K Fink, J Boratyński… - Coordination Chemistry …, 2023 - Elsevier
It has been almost 50 years since the term “supramolecular chemistry” was coined to
describe chemistry beyond the molecule. Since its beginning, supramolecular chemistry has …

Transition metal-induced B–H functionalization of o-carborane

X Zhang, H Yan - Coordination Chemistry Reviews, 2019 - Elsevier
Transition metal-mediated B–H functionalization of carboranes has drawn increasing
interests during the last two decades. This review describes how to incorporate B–H …

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… <? ACS-CT-START-Insert?> Douvris<? ACS … - Chemical …, 2013 - ACS Publications
Polyhedral boranes and carborane clusters are characterized by delocalized electron
deficient bonding, meaning that there are too few valence electrons for bonding to be …

Chemistry of the Carba-closo-dodecaborate(−) Anion, CB11H12-

S Körbe, PJ Schreiber, J Michl - Chemical reviews, 2006 - ACS Publications
Polyhedral borane and carborane clusters are characterized by delocalized electron-
deficient bonding, meaning that there are too few valence electrons for bonding to be …