Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …

Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …

Background The data on incidence, clinical presentation, and outcomes of ventilator-
associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) …

Management of patients with infections caused by multidrug-resistant organisms is
challenging and requires a multidisciplinary approach to achieve successful clinical …

Importance Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …

An optimal antimicrobial dose provides enough drug to achieve a clinical response while
minimizing toxicity and development of drug resistance. There can be considerable …

Therapeutic drug monitoring (TDM) opens the door to personalized medicine, yet it is
infrequently applied to β‐lactam antibiotics, one of the most commonly prescribed drug …

Sepsis-associated encephalopathy is a severe neurologic syndrome characterized by a
diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of …

Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …