Mechanisms of microtubule organization in differentiated animal cells

A Akhmanova, LC Kapitein - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

Control of microtubule organization and dynamics: two ends in the limelight

A Akhmanova, MO Steinmetz - Nature reviews Molecular cell biology, 2015 - nature.com
Microtubules have fundamental roles in many essential biological processes, including cell
division and intracellular transport. They assemble and disassemble from their two ends …

Building the neuronal microtubule cytoskeleton

LC Kapitein, CC Hoogenraad - Neuron, 2015 - cell.com
Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity …

Microtubule-organizing centers: from the centrosome to non-centrosomal sites

AD Sanchez, JL Feldman - Current opinion in cell biology, 2017 - Elsevier
The process of cellular differentiation requires the distinct spatial organization of the
microtubule cytoskeleton, the arrangement of which is specific to cell type. Microtubule …

Microtubule organization, dynamics and functions in differentiated cells

A Muroyama, T Lechler - Development, 2017 - journals.biologists.com
Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …

Microtubule nucleation: beyond the template

J Roostalu, T Surrey - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Microtubules are cytoskeletal filaments central to a wide range of essential cellular functions
in eukaryotic cells. Consequently, cells need to exert tight control over when, where and how …

Microtubule-organizing centers

J Wu, A Akhmanova - Annual review of cell and developmental …, 2017 - annualreviews.org
The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …

ReMAPping the microtubule landscape: How phosphorylation dictates the activities of microtubule‐associated proteins

A Ramkumar, BY Jong… - Developmental …, 2018 - Wiley Online Library
Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition

K Jiang, S Hua, R Mohan, I Grigoriev, KW Yau, Q Liu… - Developmental cell, 2014 - cell.com
Microtubules are cytoskeletal polymers with two structurally and functionally distinct ends,
the plus-and the minus-end. Here, we focus on the mechanisms underlying the regulation of …

Microtubule minus-end-targeting proteins

A Akhmanova, CC Hoogenraad - Current Biology, 2015 - cell.com
Microtubules are cytoskeletal filaments that are intrinsically polarized, with two structurally
and functionally distinct ends, the plus end and the minus end. Over the last decade …