Introduction: There is a high prevalence of methotrexate (MTX) use in males of reproductive
age. The scope of this paper reviews what is known regarding risks to fertility and partners' …

DNA integrity is considered an important parameter of semen quality and is of significant
value as a predictor of male fertility. Currently, there are several methods that can assess …

Methotrexate (MTX) is a chemotherapeutic medicine used in the treatment of several types
of cancer and inflammatory diseases. It exhibits several drawbacks especially on highly …

Thymoquinone is the major active component derived from Nigella sativa. Methotrexate is a
folic acid antagonist widely used in clinic. Aim of this study was to investigate the possible …

Methotrexate (MTX) is an anti-metabolite widely used in the treatment of neoplastic
disorders, rheumatoid arthritis and psoriasis. The basis for its therapeutic efficacy is the …

This study aimed to determine the protective effects of co-administration of Quercetin (QT) or
l-Carnitine (LC) against the oxidative stress induced by Atrazine (ATZ) in the reproductive …

Methotrexate (MTX; 4‐amino‐10‐methylfolic acid) is a folic acid reductase inhibitor used to
treat autoimmune diseases and certain types of cancer. Testicular toxicity resulting from MTX …

Ginkgo biloba leaf extract (GIN) is a popular Chinese herbal medicine. It has a
nephroprotective effect against the nephrotoxicity induced by the chemotherapeutic agent …

To investigate the effect of carvacrol (CAR) on methotrexate (MTX)-induced testis damage in
rats. Twenty-four male rats were equally divided into three groups: group I control treatment; …

Doxorubicin is a widely used chemotherapeutic agent causing serious dose-dependent
toxicity to non-target tissues such as testis. Its testicular toxicity is mainly due to the induction …