Cyclin-dependent kinases (CDKs) are serine/threonine kinases whose catalytic activities are
regulated by interactions with cyclins and CDK inhibitors (CKIs). CDKs are key regulatory …

Presently, breast cancer (BC) is one of the most common malignancies diagnosed and the
leading cause of tumor-related deaths among women worldwide. Cell cycle dysregulation is …

Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are
treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase …

Cyclin-dependent kinase 8 (CDK8), as a kinase subunit of the Mediator complex, is involved
in the regulation of RNA polymerase II-mediated transcription, thereby modulating multiple …

The CDK8–cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C
remains undruggable. Modulators regulating cyclin C activity directly are still under …

Eleven previously undescribed alkaloids, including three pairs of enantiomers
nitidumalkaloids A–C, a pair of scalemic mixtures nitidumalkaloid D and three optically pure …

Abstract Cyclin-dependent kinase 8 (CDK8) plays an momentous role in transcription
regulation by forming kinase module or transcription factor phosphorylation. A large number …

Nine new sesquiterpene alkaloids, eurochevalierines A–I (1–9), were separated from the
rice cultures of the endophytic fungus Penicillium sp. HZ-5 originated from the fresh leaf of …

A new bicyclic macrolide, hamuramicin C (1), was isolated from Streptomyces sp. MBP16, a
gut bacterial strain of the wasp Vespa crabro flavofasciata. Its 22-membered macrocyclic …

Triple‐negative breast cancer (TNBC) is caused due to the lack of estrogen receptors (ER),
progesterone receptors (PR), and human epidermal growth factor 2 (HER2) expression …