Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

The RAS oncogenes were identified almost 20 years ago. Since then, we have learnt that
they are members of a large family of small GTPases that bind GTP and hydrolyse it to GDP …

Epidermal growth factor receptor (EGFR) signaling was analyzed in mammalian cells
conditionally defective for receptor-mediated endocytosis. EGF-dependent cell proliferation …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

Growing evidence suggests that phosphoinositides play an important role in membrane
traffic. A polyphosphoinositide phosphatase, synaptojanin 1, was identified as a major …

Determinants of membrane targeting of Rho proteins were investigated in live cells with
green fluorescent fusion proteins expressed with or without Rho-guanine nucleotide …

Endocytosis of cell-surface proteins via specific pathways is critical for their function. We
show that multiple glycosylphosphatidylinositol-anchored proteins (GPI-APs) are …

Rho, Rac and Cdc42 are three Ras-related GTP-binding proteins that control the assembly
and disassembly of the actin cytoskeleton in response to extracellular signals. During the …

Clathrin-dependent endocytosis has long been presented as the only efficient mechanism
by which transmembrane receptors are internalized. We selectively blocked this process …