C Peteranderl, S Herold… - Seminars in respiratory …, 2016 - thieme-connect.com
Seasonal and pandemic influenza are the two faces of respiratory infections caused by influenza viruses in humans. As seasonal influenza occurs on an annual basis, the …
P Anderson, N Kedersha - Cell stress & chaperones, 2002 - ncbi.nlm.nih.gov
Eukaryotic cells express a family of eukaryotic translation initiation factor 2 alpha (eIF2α) kinases (eg, PKR, PERK-PEK, GCN2, HRI) that are individually activated in response to …
EA Bowling, JH Wang, F Gong, W Wu, NJ Neill, IS Kim… - Cell, 2021 - cell.com
Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …
M Vareille, E Kieninger, MR Edwards… - Clinical microbiology …, 2011 - Am Soc Microbiol
The airway epithelium acts as a frontline defense against respiratory viruses, not only as a physical barrier and through the mucociliary apparatus but also through its immunological …
A conserved biological response to double-stranded RNA, known variously as RNA interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …
DL Eizirik, AK Cardozo, M Cnop - Endocrine reviews, 2008 - academic.oup.com
Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the pathogenesis of diabetes, contributing to pancreatic β-cell loss and insulin resistance …
Protein kinase RNA-activated (PKR) induces immune response by sensing viral double- stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be …
RNA interference (RNAi) was first recognized in Caenorhabditis elegans as a biological response to exogenous double-stranded RNA (dsRNA), which induces sequence-specific …
Among the 3 billion base pairs of the human genome, there are∼ 30,000–40,000 protein- coding genes, but the function of at least half of them remains unknown. A new tool—short …