Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development
and homeostasis. Impaired microglial functions are thought to be involved in the onset and …

To better define roles that astrocytes and microglia play in Alzheimer's disease (AD), we
used single-nuclei RNA-sequencing to comprehensively characterise transcriptomes in …

While epidermal growth factor receptor (EGFR) has been shown to be important in the entry
process for multiple viruses, including hepatitis C virus (HCV), the molecular mechanisms by …

Disialosyl globopentaosylceramide (DSGb5) is a tumor-associated complex
glycosphingolipid. However, the accessibility of structurally well-defined DSGb5 for precise …

Neutrophils play a critical role in the host defense against infection, and they are able to
perform a variety of effector mechanisms for this purpose. However, there are also a number …

Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory
receptor that recognizes specific O-glycosylated proteins and is expressed on various innate …

This review is the sixth update of the original article published in 1999 on the application of
MALDI mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings …

All cells in nature are covered with a dense and complex array of glycan chains. Specific
recognition and binding of glycans is a critical aspect of cellular interactions, both within and …

Alzheimer's disease (AD) is an ever more common neurodegenerative disease among the
elderly, characterized by recurrent neuroinflammation and amyloid beta (Aβ) accumulation …