Bone is a highly vascularized tissue, and its development, maturation, remodeling, and
regeneration are dependent on a tight regulation of blood vessel supply. This condition also …

Publisher Summary This chapter focuses on structure and expression of interleukin-6 (IL-6),
which is a cytokine with pleiotropic activities that plays a central role in host defense. IL-6 …

INEFFICIENT vascular supply and the resultant reduction in tissue oxygen tension often lead
to neovascularization in order to satisfy the needs of the tissue1. Examples include the …

Abstract IL-6−/− mice showed impaired leukocyte accumulation in subcutaneous air
pouches. Defective leukocyte accumulation was not due to a reduced migratory capacity of …

I. Introduction THE existence of mechanisms that provide immunity to an infective agent was
inferred from empirical observations obtained through the ingenuity and deductive capacity …

Cytokines are thought to be important mediators in physiologic and pathophysiologic
processes affecting the central nervous system (CNS). To explore this hypothesis …

Angiogenesis, the formation of new blood vessels, is induced by various growth factors and
cytokines that act either directly or indirectly. Vascular endothelial growth factor (VEGF) is a …

IL6 is a multifunctional cytokine with pivotal roles in the inflammatory response and in
directing T cell differentiation in adaptive immunity. IL6 is widely expressed in the female …

Inflammation plays a role in the initiation and development of many types of cancers,
including epithelial ovarian cancer (EOC) and high grade serous ovarian cancer (HGSC), a …

Abstract Interleukin-6 (IL-6) has received particular attention in the pathogenesis of cervical
cancer, although the underlying mechanism remains elusive. This study revealed that IL-6 …