Skeletal muscle fibers express distinct gene programs during development and maturation,
but the underlying gene regulatory networks that confer stage-specific myofiber properties …

The single‐cell revolution in the field of genomics is in full bloom, with clever new molecular
biology tricks appearing regularly that allow researchers to explore new modalities or scale …

Myofibres serve as the functional unit for locomotion, with the sarcomere as fundamental
subunit. Running the entire length of this structure are hundreds of myonuclei, located at the …

Fatty infiltration, the ectopic deposition of adipose tissue within skeletal muscle, is mediated
via the adipogenic differentiation of fibro-adipogenic progenitors (FAPs). We used single …

Skeletal muscle fiber is a large syncytium with multiple and evenly distributed nuclei. Adult
subsynaptic myonuclei beneath the neuromuscular junction (NMJ) express specific genes …

Duchenne muscular dystrophy is an X-linked monogenic disease caused by mutations in
the dystrophin gene (DMD) characterized by progressive muscle weakness, leading to loss …

Congenital pseudarthrosis of the tibia (CPT) is a severe pathology marked by spontaneous
bone fractures that fail to heal, leading to fibrous nonunion. Half of patients with CPT are …

Differentiated cardiomyocytes (CMs) must undergo diverse morphological and functional
changes during postnatal development. However, the mechanisms underlying initiation and …

Single nuclei RNA sequencing (snRNA-seq) has evolved as a powerful tool to study
complex human diseases. Single cell resolution enables the study of novel cell types …

Background Tumour‐induced skeletal muscle wasting in the context of cancer cachexia is a
condition with profound implications for patient survival. The loss of muscle mass is a …