HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation
and cell death, HMGB1 can function as an alarm protein (alarmin) or damage-associated …

Ethnopharmacological relevance A great deal of valuable experience has been
accumulated in the traditional Chinese medicine (TCM) system for the treatment of “Xiaoke” …

Diabetes mellitus is a common metabolic disorder. About two-thirds of diabetic patients
develop diabetic cardiomyopathy (DCM), which becomes a challenging issue as it severely …

Diabetes induces a decrease in the number and function of different pro-angiogenic cell
types generically designated as putative endothelial progenitor cells (EPC), which …

One of the major reasons for the delayed wound healing in diabetes is the dysfunction of
endothelial progenitor cells (EPCs) induced by hyperglycaemia. Improvement of EPC …

Background Heart failure with preserved ejection fraction (HFpEF) remains an increasing
public health problem with substantial morbidity and mortality but with few effective …

Methotrexate (MTX), a chemotherapeutic antimetabolite, has been linked to cognitive
impairment in cancer patients. MTX-induced metabolic pathway disruption may result in …

Diabetes mellitus (DM) is an endemic disease, with growing health and social costs. The
complications of diabetes can affect potentially all parts of the human body, from the heart to …

Diabetes mellitus (DM) is considered a leading cause of premature cardiovascular (CV)
mortality and morbidity in general population and in individuals with known CV disease …

Previous researches have emphasized a trypsin-centered theory of acute pancreatitis (AP)
for more than a century. With additional studies into the pathogenesis of AP, new …