Vibrio cholerae is a gram-negative bacterium that is the causative agent of cholera. This
disease consists of enormous fluid loss through stools, which can be fatal. Cholera …

ABSTRACT The Gram-negative bacterium Vibrio cholerae is responsible for the severe
diarrheal pandemic disease cholera, representing a major global public health concern …

Related organisms typically respond to a given cue by altering the level or activity of
orthologous transcription factors, which, paradoxically, often regulate expression of distinct …

To be successful pathogens, bacteria must often restrict the expression of virulence genes to
host environments. This requires a physical or chemical marker of the host environment as …

ToxR, a Vibrio cholerae transmembrane one-component signal transduction factor, lies
within a regulatory cascade that results in the expression of ToxT, toxin coregulated pilus …

A common mechanism inhibiting the activity of transcription factors is their sequestration to
the membrane until they are needed, at which point they are released from the membrane …

AphA is required for expression of the Vibrio cholerae virulence cascade and for its
regulation by quorum sensing. In order to activate transcription, AphA functions together with …

Expression of toxT, the transcription activator of cholera toxin and pilus production in Vibrio
cholerae, is the consequence of a complex cascade of regulatory events that culminates in …

ToxR facilitates TcpP-mediated activation of the toxT promoter in Vibrio cholerae, initiating a
regulatory cascade that culminates in cholera toxin secretion and toxin coregulated pilus …

Two of the primary virulence regulators of V ibrio cholerae, ToxR and TcpP, function together
with cognate effector proteins. ToxR undergoes regulated intramembrane proteolysis (RIP) …